Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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CardiacSense, an Israel-based healthcare technology company, gained FDA clearance for its CSF-3 medical watch

Regulatory Roundup: FDA clears new medical watch, considers empagliflozin for CKD and much more

Our monthly review of FDA-related news items in the world of cardiology includes updates from CardiacSense, MedAlliance, Lupin, Realize Medical and Eli Lilly and Company. 

January 31, 2023
Product Recall

FDA announces new IABP recall after 4 serious injuries, 1 death

The new recall includes nearly 4,500 devices. There have been 134 incidents so far, including 5 adverse events.  

January 25, 2023
An example if an implantable cardioverter defibrillator (ICD and its leads connected to the heart. As the leads or deveice wears out, there are recommendations to remove the leads and put in new ones. The most common causes of mortality during transvenous lead removal (TLR) in patients with cardiac implantable electronic devices (CIEDs) are infection and decompensated heart failure, according to new research published in JACC: Clinical Electrophysiology.Image courtesy of RSNA

Infection, heart failure the most common reasons for early mortality after transvenous lead removal

Early mortality specifically related to complications during the TLR procedure was quite rare. 

January 20, 2023
The Abbott HeartMate 3 left ventricular assist system. When Medicare updated its policy on left ventricular assist devices (LVADs) in 2020, making it easier for heart failure patients to receive an LVAD at a health center that does not perform heart transplants, the change was designed to improve patient access and boost outcomes. However, new research published in JAMA Network Open suggests shift may have potentially caused patients to miss out on heart transplants they would have otherwise received.

Medicare update designed to help heart failure patients may have the opposite effect

When Medicare made it easier for heart failure patients to receive a LVAD at a hospital that does not perform heart transplants, the change was intended to improve patient access. It turns out, however, that the policy shift could be linked to an unintended consequence. 

January 12, 2023
hospital ward

Why cardiologists should pay close attention to rehospitalizations after TAVR or SAVR

A new analysis in Circulation: Cardiovascular Interventions examined rehospitalization rates after AVR, noting that they are consistently associated with worse outcomes and a higher risk of patient mortality.

January 6, 2023
The Dexcom G7 Continuous Glucose Monitoring System

Regulatory Roundup: FDA news on omecamtiv mecarbil for HFrEF, 'world's smallest heart pump' and more

Read our monthly recap of some of the biggest FDA-related stories that have hit cardiology, including updates related to Cytokinetics, Dexcom and Abiomed. 

December 22, 2022
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AI specialists ink deal with Pfizer to target cardiac amyloidosis

Cardiac amyloidosis can be especially challenging to identify and diagnose, making it a perfect target for advanced AI models.

December 20, 2022
Researchers found the reason radiation and anthracyclines in some patients causes cardio toxicity may be due to the cGAS–STING pathway. This holds great potential as a treatment to prevent cardiac complications of DNA-damaging cancer treatments in new cardio-oncology research. Pathology Laboratory

New discovery could reduce the risk of heart damage among cancer patients

Researchers have identified new details about the link between certain cancer therapies and heart complications. Could their work lead to key improvements in patient care?

December 19, 2022
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