Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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Illustration showing four innovative heart failure technologies: The V-Wave interaterial shunt to relieve pressures between the left and right sides of the heart; the Carillon Transcatheter mitral valve annuloplasty system; the Revivent TC system and the AccuCinch device. Interventional cardiology heart failure cleveland clinic

4 promising heart failure therapies interventional cardiologists should keep an eye on

The devices, currently being investigated by teams of heart specialists, could make a big impact in the years ahead. 

May 3, 2022
mavacamten

FDA approves mavacamten for obstructive hypertrophic cardiomyopathy

The FDA’s approval was based on data from the EXPLORER-HCM trial, which showed that mavacamten was superior to a placebo for treating obstructive HCM and associated with no significant long-term, treatment-related adverse events.

May 2, 2022
The U.S. Food and Drug Administration (FDA) is alerting healthcare providers to the possibility that patients who have a Medtronic Heartware Ventricular Assist Device (HVAD) System and present with pump thrombosis may have a welding defect in the internal pump, causing it to malfunction. Medtronic and the FDA issues the notice to providers April 28, 2022.

Internal pump malfunction in the Medtronic HVAD found in three patients

The FDA and Medtronic warn some Heartware Ventricular Assist Device (HVAD) systems have a defect that may cause pump thrombosis.

April 29, 2022
Heart failure hospitalizations among young adults are getting more common and more expensive

Heart failure hospitalizations among young adults are getting more common and more expensive

Researchers examined data from more than 750,000 heart failure hospitalizations, sharing their findings in JACC: Heart Failure. 

April 28, 2022
Machinist Patrick Leibich of Penn State College of Medicine’s division of Applied Biomedical Engineering works to create artificial heart parts. Image courtesy of Penn State.

Penn State researchers receive more than $3 million to develop new-look artificial heart

The group will be working to develop a wireless artificial heart that can last at least 10 years. 

April 25, 2022
The new recall includes five lots of medications distributed from December 2019 to April 2022. Similar products were also recalled back in March for the same reason. The FDA recalled Accupril from Pfizer.

FDA announces another recall of common hypertension medication due to potential cancer risk

The new recall includes five lots of medications distributed from December 2019 to April 2022. Similar products were also recalled back in March for the same reason.

April 25, 2022
TricValve Transcatheter Bicaval Valves System Cleveland Clinic. Image courtesy of P + F Products + Features GmbH.

Interventional cardiologists complete first heart procedure of its kind in North America

While the system used during the procedure has not yet gained full FDA approval, this patient was treated under a compassionate-use clearance from the agency.

April 19, 2022
Patient doctor with masks. A team of specialists from Cleveland Clinic reviewed nearly 3,000 medications, writing that a common type 2 diabetes medication offered the most potential as an effective treatment for AFib. 

Women who experience infertility may face higher heart failure risk

Researchers examined the health outcomes of 38,528 postmenopausal women—14% of whom had a history of infertility—over a 15-year period. 

April 19, 2022
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