Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

Novartis HF drug sacubitril/valsartan fails trial

Swiss drugmaker Novartis on July 29 announced its combo sacubitril/valsartan drug Entresto “narrowly missed” its primary endpoint in the Phase III PARAGON-HF study, throwing into question the future of a blockbuster drug.

July 29, 2019

Global study connects cancer, takotsubo cardiomyopathy

A study published July 17 in the Journal of the American College of Cardiology has revealed a strong link between cancer and takotsubo cardiomyopathy, or “broken heart syndrome.”

July 19, 2019
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Methamphetamine abuse exacerbates HF in growing number of veterans

Methamphetamine abuse is on the rise among veterans with concomitant heart failure, according to a recent analysis published in the American Journal of Cardiology

July 17, 2019

Malleable polymers could contribute to development of artificial hearts

Researchers in Italy are developing “smart,” photo-responsive materials they hope will replicate the mechanical properties of a human heart in an artificial format, Cosmos Magazine reported July 12.

July 12, 2019
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A Path for Concurrent Cardiac & Palliative Care

The Center to Advance Palliative Care suggests steps cardiologists can take to ensure ongoing identification and management of remediable sources of suffering and distress in heart failure patients.

July 12, 2019

Sacubitril/valsartan well-covered, but still unaffordable for many with HFrEF

The combination heart failure drug sacubitril/valsartan is well-covered under Medicare Part D plans, according to a recent analysis, but patient access to the medication remains limited by steep out-of-pocket costs than can exceed $1,600 annually.

July 12, 2019

HIV elevates risk of heart failure, stroke

A large-scale study of people living with HIV has linked the immune deficiency to an increased risk of CVD, in particular heart failure and stroke.

July 8, 2019
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Financial incentives boost participation in cardiac rehab

Heart patients of a lower socioeconomic status are far more likely to participate in cardiac rehabilitation if they receive financial incentives to attend sessions, according to a study published in the July 1 edition of JACC: Heart Failure.

July 8, 2019

Around the web

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

Kate Hanneman, MD, explains why many vendors and hospitals want to lower radiology's impact on the environment. "Taking steps to reduce the carbon footprint in healthcare isn’t just an opportunity," she said. "It’s also a responsibility."

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