Heart Failure

Heart failure occurs when the heart cannot pump as much blood as the body requires. This ineffective pumping can lead to enlargement of the heart as the myocardium works harder pump the same amount of blood. Heart failure may be caused by defects in the myocardium, such as an a heart attack infarct, or due to structural issues such as severe heart valve regurgitation. Heart failure can be divided into HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). The disease is further divided into four New York Heart Association (NYHA) classes. Stage IV heart failure is when the heart is completely failing and requires a heart transplant or hemodynamic support from a left ventricular assist device (LVAD).

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CV outcomes underreported in pivotal anticancer trials

A recent review of pivotal cancer drug trials suggests that CVD and adverse cardiovascular outcomes are underreported in studies of new cancer therapies, despite an increasing risk of cardiotoxicity in oncological drugs.

February 11, 2020

Palliative care needs projected to nearly double over next 30 years

Research out of Ireland suggests end-of-life care needs will nearly double over the next three decades, corresponding to an increase of 84% by 2046.

February 6, 2020
Heart AI

LVAD-supported patients suffer from ‘severely impaired’ exercise capacity

Despite other quality of life improvements, heart patients supported by left ventricular assist devices face “severely impaired” exercise capacity, according to a study published online in JACC: Heart Failure.

February 6, 2020
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Making history: Lab-grown cardiomyocytes successfully transplanted for 1st time

Lab-growing cardiomyocytes have been transplanted into a human patient for the first time in medical history, according to a report from the Japan Times.

January 31, 2020

Cancer drug could be repurposed to treat HFpEF

Scientists have uncovered a potential new treatment for heart failure with preserved ejection fraction (HFpEF)—and it’s one that already exists.

January 30, 2020
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Study proves diabetes is an independent predictor of HF

A cross-structural analysis published in Mayo Clinic Proceedings this January independently links diabetes to the development of heart failure, suggesting diabetic cardiomyopathy is a real—and growing—issue in the U.S.

January 15, 2020

FDA grants dapagliflozin priority review for treatment of HFrEF

Drugmaker AstraZeneca announced Jan. 6 that its SGLT2 inhibitor dapagliflozin, sold commercially as Farxiga, had been granted Priority Review by the FDA for patients with heart failure with reduced ejection fraction.

January 7, 2020
Large peridevice leaks after left atrial appendage occlusion (LAAO) are incredibly rare and not associated with a greater risk of adverse outcomes, according to new research published in JACC: Clinical Electrophysiology.[1] Smaller residual links are more common, however, and associated with a risk of thromboembolic and bleeding events.

Cases of chronic HF expected to reach 32M by 2028

Diagnosed cases of chronic heart failure are expected to number 32 million by 2028, according to a report from analytics company GlobalData.

December 10, 2019
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