Cardiologist in Cleveland receives NIH’s outstanding investigator award

Mukesh K. Jain, MD, a cardiologist and the chief scientific officer at University Hospitals Cleveland Medical Center and the Harrington Discovery Institute, received an outstanding investigator award from the National Institutes of Health (NIH).

Jain plans on using the seven-year, $6.7 million dollar award from the National Heart, Lung and Blood Institute to study age-related cardiovascular risks.

Sanford Markowitz, MD, PhD, an oncologist from Case Western Reserve University School of Medicine, received the same award from the National Cancer Institute. Markowitz will use the money to study colon cancer.

Jain is known for identifying Kruppel-like factors (KLFs), a family of proteins that are key regulators of immunity and metabolism. He will use the award to study which KLFs are linked to aging and understand how manipulating KLFs impacts cardiovascular health and age-associated disease.

“Mukesh’s lifelong commitment to investigating the molecular mechanisms of cardiovascular diseases has led to discoveries that forever changed how we think about many fundamental biological processes that affect human health and aging,” Marco Costa, MD, PhD, president of the Harrington Heart & Vascular Institute and University Hospitals Cleveland Medical Center, said in a news release. “Receiving this prestigious award is an acknowledgement of the breadth and depth of his work, and our promise to a healthier future for humankind.”