Lipids & Metabolic

Rapidly growing rates of obesity and diabetes—already threats to global health—will likely have fatal consequences in the case of a future flu pandemic, the Telegraph reported this week.

The deal Regeneron and Sanofi cut with Express Scripts to lower the prices of their PCSK9 inhibitor in exchange for simpler preauthorization forms has opened the floodgates for another two dozen such deals for the cholesterol-lowering drug class, the New York Times reported.

As an adjunct to standard treatment for patients with type 2 diabetes, liraglutide appears at least as protective against cardiovascular events for patients with chronic kidney disease (CKD) as for those without CKD, according to a subgroup analysis of the LEADER trial published in Circulation.

Women who experience menopause before age 40 are twice as likely to develop type 2 diabetes (T2D) than those who reach menopause at a more normal age, according to research presented at the European Association for the Study of Diabetes’ annual conference in Berlin last week.

A low measure of base excess (BE) upon admission to the ICU following cardiac surgery was independently predictive of ICU mortality—more so than increased lactate levels, researchers reported in PLOS One.

Lorcaserin, an appetite suppressant approved for chronic weight management in 2012, reduced overweight patients’ risk for developing type 2 diabetes (T2D) and improved remission of hyperglycemia in a study of more than 12,000 Massachusetts residents, researchers reported.

Metabolic parameters like body weight, blood pressure, cholesterol and blood sugar levels are established risk factors for cardiovascular disease. But a new study suggests it’s not just abnormal measures of these components that portend risk—significant fluctuations in these areas are independently linked to all-cause mortality, heart attack and stroke among otherwise healthy people.

An increased intake of vitamin B, paired with routine ACE inhibitor therapy, could help protect kidney function in kids and teens with type 1 diabetes (T1D), according to a study presented at the 57th annual European Society for Pediatric Endocrinology Meeting in Athens, Greece.

Biopharmaceutical company Amarin this week announced the topline results of its REDUCE-IT trial, a global study that achieved 25 percent cardiovascular risk reduction in a population of 8,179 statin-treated adults with the daily use of Vascepa, also known as icosapent ethyl.

A report published by charity organization Cancer Research U.K. suggests obesity is on track to eclipse smoking as the greatest cause of preventable cancer in British women—something experts say could happen by 2043, the Guardian has reported.

Women who most closely adhere to a Mediterranean-style diet could be lowering their risk of stroke by up to 22 percent, according to 17-year results of a large-scale study out of the United Kingdom.

The U.S. Preventive Services Task Force (USPSTF) suggested clinicians continue to offer intensive, multicomponent behavioral interventions for adults with obesity in an updated recommendation statement published Sept. 18 in JAMA.