Hypertension

An ongoing FDA investigation of generic angiotensin II receptor blocker (ARB) drugs used to treat hypertension and heart failure found higher-than-acceptable levels of the carcinogen N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) in recent batches of losartan potassium tablets, prompting a voluntary recall of 87 lots, the agency announced March 1. NMBA is the third different carcinogenic impurity recently discovered in ARBs.

A recently published mouse study may offer clues about why premenopausal women are less prone than men to “nondipping hypertension,” a condition in which blood pressure doesn’t drop its normal 10 to 20 percent at night.

A half-hour walk in the morning lowers blood pressure (BP) in overweight and obese men and women predisposed to heart disease, according to a study published in Hypertension Feb. 20.

A national cardiovascular disease screening project in China revealed fewer than 3 percent of high-risk participants were taking either statins or aspirin—a finding researchers described as a “wake-up call” for middle- and low-income countries which are struggling to combat their worsening CVD risk profiles.

An analysis of sex-related differences in cardiovascular risk factors, treatment and control in the U.S. has revealed women have a better handle on their high blood pressure than men, but they also fare worse in terms of cholesterol and obesity.

The American Heart Association announced on Feb. 20 it launched a series of quick online reference tools for physicians and their patients who struggle with high blood pressure, including a list of four of the most common mistakes hypertensives can make on a daily basis.

Though many physicians are reluctant to change the status quo, a study published in JAMA Internal Medicine Feb. 4 suggests automated office blood pressure measurement (AOBP) is the way to go when recording a patient’s BP, since the approach bypasses the so-called “white coat effect” triggered by more traditional methods.

There’s not much aging individuals can do to beat back age-related cognitive impairment once it begins, but improving consistency in blood pressure seems to help slow the pace of the falloff in those with significant BP swings.

ProvideGx, a subsidiary of Premier, will begin its offerings with metoprolol, a beta-blocker that can treat blood pressure and angina and is commonly given to heart attack patients.

Rates of CVD in the U.S. are climbing for the first time in decades, the American Heart Association announced Jan. 31 in its annual heart and stroke statistical update. The organization also said nearly half of the adult U.S. population has some form of heart disease.

Full results from the SPRINT MIND trial, published Jan. 28 in JAMA, suggest intensive blood pressure control at a systolic target of less than 120 mm Hg could reduce the likelihood of mild cognitive impairment (MCI) that leads to dementia and Alzheimer’s.

A study of Native Americans who experienced ischemic stroke showed they carried a high burden of risk factors, nearly all of which grew in prevalence from 2000 to 2016.