Hypertension

In the largest-ever randomized trial of antihypertensive drug treatment in sub-Saharan Africa, two medication combinations including the long-acting calcium channel blocker amlodipine outperformed a third two-drug combination featuring a diuretic and an angiotensin-converting-enzyme (ACE) inhibitor.

Hypertensive patients from the RADIANCE-HTN SOLO trial who received renal denervation sustained a lower blood pressure through six months compared to participants randomized to a sham procedure, despite being placed on fewer antihypertensive medications during follow-up.

The CDC has released a new fact sheet on the burden of chronic kidney disease (CKD) in the U.S., highlighting its relationship to cardiovascular disease and noting that 15 percent of American adults—or 37 million people—have CKD.

The FDA fast-tracked the approval process for a new generic valsartan product (Diovan) amid an ongoing shortage of the blood pressure and heart failure medication.

A napping habit could lower blood pressure to a similar extent as other lifestyle modifications and some drugs, according to research scheduled to be presented March 18 at the American College of Cardiology’s scientific sessions in New Orleans.

The SPRINT trial suggested a more aggressive blood pressure-lowering target reduced the rate of cardiovascular events in hypertensive people, but a new secondary analysis of the trial indicates such an approach may actually be harmful for smokers.

In its first scientific statement on accurately measuring blood pressure in 14 years, the American Heart Association gave a stronger recommendation for oscillometric devices and updated the evidence surrounding ambulatory and home blood pressure monitoring techniques.

An ongoing FDA investigation of generic angiotensin II receptor blocker (ARB) drugs used to treat hypertension and heart failure found higher-than-acceptable levels of the carcinogen N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) in recent batches of losartan potassium tablets, prompting a voluntary recall of 87 lots, the agency announced March 1. NMBA is the third different carcinogenic impurity recently discovered in ARBs.

A recently published mouse study may offer clues about why premenopausal women are less prone than men to “nondipping hypertension,” a condition in which blood pressure doesn’t drop its normal 10 to 20 percent at night.

A half-hour walk in the morning lowers blood pressure (BP) in overweight and obese men and women predisposed to heart disease, according to a study published in Hypertension Feb. 20.

A national cardiovascular disease screening project in China revealed fewer than 3 percent of high-risk participants were taking either statins or aspirin—a finding researchers described as a “wake-up call” for middle- and low-income countries which are struggling to combat their worsening CVD risk profiles.

An analysis of sex-related differences in cardiovascular risk factors, treatment and control in the U.S. has revealed women have a better handle on their high blood pressure than men, but they also fare worse in terms of cholesterol and obesity.