New technique improves accuracy of near-infrared fluorescence imaging

The variable fluorescence attenuation of blood has been a hindrance to near-infrared fluorescence (NIRF) measurements in cardiovascular imaging. Fortunately, researchers have devised an innovative correction method in which the guidewire (GW) is coated with the fluorescent agent (ICG) and used as a reference standard in each frame, leading to a much higher accuracy. Credit: Rauschendorfer et al., doi 10.1117/1.JBO.28.4.046001

The variable fluorescence attenuation of blood has been a hindrance for accurate measurements in the new intravascular imaging modality in development. Fortunately, researchers have devised an innovative correction method in which the guidewire is coated with a fluorescent agent and used as a reference standard in each frame, leading to a much higher accuracy. Credit: Rauschendorfer et al., doi 10.1117/1.JBO.28.4.046001

NIRF imaging could help interventional cardiologists personalize care in the cath lab, but a key engineering issue needed to be solved first.