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Vascular & Endovascular

 - left thumb

The FDA approved dabigatran for the treatment of deep vein thrombosis and pulmonary embolism in certain patients.

 - Stroke, endovascular. neuroimaging, neuro

The association between aortic valve replacements (AVR) and clinical strokes may be stronger than originally believed, data from a study published April 1 in Circulation suggest.

 - Medtronic Symplicity renal denervation system

Medtronic indicated that the company is willing to support another renal denervation trial after seeing a glimmer of hope in subgroup analyses of patients with resistant hypertension. The lead investigator of the failed SYMPLICITY HTN-3 encouraged proponents to persevere, but with caution.

 - Medtronic Symplicity renal denervation system

WASHINGTON, D.C.—Renal denervation in treatment-resistant hypertensive patients lowered systolic blood pressure by only 2.39 mm Hg, falling short of the SYMPLICITY HTN-3 clinical trial’s superiority margin. Some experts at the American College of Cardiology (ACC) scientific session in Washington, D.C., suggested on March 29 that operator experience and no way to ascertain denervation occurred were factors. 

 - brain, stroke

Patients with extensive middle-cerebral-artery stroke may benefit somewhat from hemicraniectomy, based on research published March 20 in the New England Journal of Medicine. The study found the procedure improved survival, but left many patients with considerable disability.

 

 

More Stories

BP differences between arms may increase cardiovascular risk

A difference in systolic blood pressure between arms may indicate an increased risk for cardiovascular events in the future, even if the difference is modest, researchers found in a study published in the March issue of the American Journal of Medicine.

CT-based imaging on the rise in ischemic stroke patients

The use of CT angiogram and CT perfusion increased considerably among patients with acute ischemic stroke between 2006 and 2010, a study published online Feb. 25 in Stroke found.

Statins may improve survival for patients with critical limb ischemia

Patients with critical limb ischemia who use statins may live longer and also be at lower risk for amputation and major adverse cardiovascular and cerebrovascular events, a study published in the Feb. 25 issue of the Journal of the American College of Cardiology found.

Intracranial atherosclerosis may be major stroke predictor

Intracranial atherosclerosis may be a risk factor for stroke in whites and may play a role in a greater number of strokes than large-artery atherosclerosis in other vessel beds, according to a study published online Feb. 17 in JAMA Neurology.

Postpartum thrombotic risk extends to 12 weeks

Women may be at risk for thrombotic events for up to 12 weeks after delivering a baby, twice as long as previously thought, according to a study published online Feb. 13 in The New England Journal of Medicine. The findings were simultaneously presented at the International Stroke Conference in San Diego.

Weather extremes may trigger stroke

Frigid temperatures, crippling ice and snow and drought—extreme weather has raised concerns from coast to coast this year. Now add stroke to the wintry mix.

Recent cocaine use amplifies stroke risk in the young

Young adults who reported cocaine use within 24 hours had a six- to seven-fold increase in risk for ischemic stroke, according to research presented Feb. 12 at the meeting of the International Stroke Conference of the American Heart Association in San Diego. This increase is especially significant among women, even though women use cocaine less frequently.

Guidelines focus on stroke prevention in women

Women have unique risk factors for stroke, and a joint panel of experts from the American Heart Association and the American Stroke Association made recommendations that take these risk factors into account. Their guidelines were published online Feb. 6 in Stroke.

Home BP measurements may predict cardiovascular risk better

Self-measured blood pressure readings may be better predictors of cardiovascular issues or death than conventional blood pressure measurements, except among people with severe hypertension, according to a study published in the January issue of PLOS Medicine.

Covidien drops renal denervation program

Covidien pulled the plug on its renal denervation initiative, citing “slower than expected development of the renal denervation market.”

Mediterranean diet may hold off PAD in high-risk patients

The Mediterranean diet may lower the risk of peripheral artery disease (PAD), according to results published in a research letter in the Jan. 22-29 issue of JAMA.

Commonly used carotid stent systems found to be safe

Three common carotid stenting systems used in the U.S. were associated with low rates of adverse events, a study published online Jan. 15 in JACC: Cardiovascular Interventions found.

Guidelines help docs manage patients on novel anticoagulants

Although the novel oral anticoagulants dabigatran, rivaroxaban and apixaban offer alternatives to warfarin to prevent strokes in patients with atrial fibrillation, physicians may still need guidance on how to manage them.

SYMPLICITY HTN-3 falls short on effectiveness

The pivotal SYMPLICITY HTN-3 clinical trial designed to evaluate the safety and efficacy of renal denervation as a treatment for uncontrolled hypertension failed to meet its primary efficacy endpoint.

Clopidogrel plus aspirin fails to reduce risk after lacunar stroke

Adding clopidogrel does not reduce the risk of recurrent stroke in patients with a recent lacunar stroke who were taking aspirin, a subanalysis of a randomized, controlled clinical trial found.

Shingles raises later risk for vascular events

People who develop shingles between the ages of 18 and 40 may be at increased risk for a stroke, MI or a transient ischemia attack in later years, a study published online Jan. 2 in Neurology found.

Abbott pays $5M to settle kickback charges

Abbott Laboratories agreed to pay more than $5 million in a settlement over an alleged kickback scheme involving its carotid, biliary and peripheral vascular products.

Patients more vulnerable in first 30 days on warfarin

Patients with atrial fibrillation who initiate warfarin therapy may have a two-fold risk of ischemic stroke in the first 30 days of use compared with nonusers, according to a study published online Dec. 18 in the European Heart Journal.

ACEI/ARB may provide renoprotective effect

Patients with stable hypertension and advanced chronic kidney disease who take medications that block the renin-angiotensin-aldosterone system may be less likely to need long-term dialysis than similar patients not treated with these drugs. Their risk of death also may be lower, according to study published online Dec. 16 in JAMA Internal Medicine.

Novel anticoagulants reduce ICH risk better than warfarin

Novel oral anticoagulants may be the best defense against intracranial hemorrhage (ICH) when used to prevent strokes in patients with atrial fibrillation, based on the findings of a meta-analysis published in the December issue of JAMA Neurology.