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Nuclear Cardiology

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There are a few different quantitative techniques used to measure myocardial blood flow (MBF) and myocardial flow reserve (MFR), both of which have been shown to provide useful information in managing cardiovascular disease. However, MFR measurements appear to be less affected by variables of quantitation when using different arterial input functions and extraction models, according to a comparison study published today in the Journal of Nuclear Medicine.

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Angiogenic gene therapy shows promise in phase III SPECT study

Taxus Cardium Pharmaceuticals Group have announced encouraging interim phase III cardiac SPECT imaging results from the international ASPIRE (Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease) trial. Generx Ad5FGF-4 is a potential angiogenic gene therapy for the development of new vascularization. The data was presented June 24 during the 2014 BIO International Convention in the company’s home base of San Diego.

MPI finds more CAD five years after treatment

Stress myocardial perfusion scintigraphy (MPS) when conducted five years following percutaneous coronary intervention (PCI) has the potential to pinpoint addition disease in more than half of patients, according to a study published ahead of print May 14 in JACC: Cardiovascular Interventions.

Cardiovascular biomarker market could hit $7.2B by 2018

The global market for diagnostic biomarkers detecting cardiovascular disease is expected to soar steadily at a compound annual growth rate of 12.8 percent between 2013 and 2018.

ASNC now taking abstracts for 2014 scientific session

The American Society of Nuclear Cardiology (ASNC) announced Feb. 27 that abstract submissions are now being taken for the upcoming ASNC 2014 meeting scheduled for Sept. 18-21 at the Seaport World Trade Center in Boston.

Preliminary results look positive for cardiac fatty acid PET imaging

FluoroPharma Medical, based in Montclair, N.J., announced yesterday that new results from an ongoing phase II clinical trial for F-18 FCPHA cardiac PET for the diagnosis of acute coronary artery disease (CAD) were positive and providing validation for further research.

Ru-82 3D PET/CT MPI training leads to 94% inter-reader agreement

The rubidium-ARMI (alternative radiopharmaceutical for myocardial imaging) multicenter trial has established a bar for assessing myocardial perfusion imaging (MPI) that meets or even exceeds previous SPECT MPI reader scores after thorough consensus review, according to a study published Nov. 18 in the Journal of Nuclear Medicine.

PET/CT: C-reactive protein could be a precursor to cardiovascular disease

FDG uptake rose substantially in PET/CT scans of patients with higher levels of C-reative protein in their carotid arteries, pinpointing a potential biomarker for cardiovascular disease, according to an article published online Oct. 31 in the Journal of Nuclear Medicine.

PET myocardial blood flow finds under-diagnosed multivessel CAD

Evaluating myocardial blood flow (MBF) with stress-rest cardiac PET teases out more multivessel CAD than with cardiac PET or SPECT alone, both of which tend to underestimate severity of disease, according the proceedings of the 2013 American Society of Nuclear Cardiology (ASNC) 2013 Annual Meeting held Sept. 26-29 in Chicago.

ASNC 2013 in Chicago ensures that cardiologists don’t skip a beat

The 18th annual scientific session of the American Society of Nuclear Cardiology will provide a finger on the pulse of cardiac molecular imaging and medicine later this month at the Hyatt Regency in Chicago from Sept. 26 – 29.

Regadenoson stress PET/CT MPI trumps SPECT for CAD detection

Regadenoson stress Rb-82 PET/CT myocardial perfusion imaging (MPI) is highly sensitive, 92 percent, for the detection of obstructive CAD and beats SPECT MPI, according to a study published online Aug. 12 in the Journal of Nuclear Medicine.

Advanced SPECT and stress-only MPI lower occupational dose

Many studies have maintained that the most advanced SPECT cameras can significantly reduce patient dose, but what about medical staff? A new protocol of myocardial perfusion SPECT imaging combines state-of-the-art detector technology, image reconstruction and stress-only imaging, all precipitating an up to 60 percent drop in radiation exposure to healthcare workers, according to a study published May 30 in the Journal of Nuclear Medicine.

PET/CT powers MPI improvements

There are several advantages to PET/CT for myocardial perfusion imaging (MPI) including upgrades in quantitative analysis and biomarker technology that could provide a more complete evaluation of cardiovascular disease, according to a review published in the Journal of Nuclear Cardiology.

Other side of the coin: CT has advantages over SPECT for detection of stable CAD

In a companion piece that counters an opinion that SPECT is the best modality for first-line detection of CAD, separate experts argued that CT finds sub-clinical atherosclerosis and important coronary anatomy, providing earlier diagnoses and the option to be more aggressive with treatment, according to a review published April 10 in the Journal of Nuclear Cardiology.

SPECT beats CT for detection of stable CAD

Some clinicians maintain that cardiac-computed tomography angiography (CCTA) bests SPECT/CT for the detection of CAD, but two expert nuclear cardiologists suggest the opposite and presented data to demonstrate their case, in a study published April 10 in the Journal of Nuclear Cardiology.

In a heartbeat: Cardiac FDG PET/MR effective, beneficial for ischemia

Simultaneous PET/MR broke additional ground toward clinical use by showing technical success and potential clinical merit for FDG PET/MR detection of ischemic heart disease, according to a study published May 7 in Radiology.

The power of exercise: SPECT MPI in active patients may be unnecessary

Many older patients undergoing an exercise stress test may not need molecular imaging to provide a clear picture of cardiovascular health. Evidence suggests that SPECT MPI may not provide any additional information for those who are nimble enough to reach a certain level of exertion and show no signs of CAD or cardiovascular distress. These and similar findings point to potential radioisotope injection guidelines to reduce radiation dose and cost of healthcare for these patients, according to research presented at the International Conference on Nuclear Cardiology and Cardiac CT, held May 5 to 8 in Berlin.

Add it up: Quantifying myocardial perfusion reserve w/ SPECT viable

Researchers are developing a method of quantitative myocardial perfusion imaging that analyzes myocardial perfusion reserve using SPECT with advanced cadmium zinc telluride crystal detectors to unlock extent of coronary artery disease, according to a study published April 11 by The Journal of Nuclear Medicine.

CZT SPECT accurately quantifies ejection fraction

While myocardial perfusion imaging using cadmium-zinc-telluride (CZT) SPECT cameras accurately measures left ventricular ejection fraction, the method underestimates left ventricular volumes, according to a study published online Feb. 5 in the Journal of Nuclear Medicine.

Positron subsidiary nets FDA drug master file for Sr-82

Positron's subsidiary, Manhattan Isotope Technology, has received an acknowledgment letter and Drug Master File number assignment from the FDA for its strontium-82 drug substance.