CT-based Mobile Stroke Care

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Mobile-Stroke-Ambulance.jpg - Stephanie Parker, RN
Stephanie Parker, RN, looks at the CT scanner installed inside the UTHealth Mobile Stroke Unit.
Source: Memorial Hermann-Texas Medical Center

Germany's ground-breaking use of CT scanners in ambulances to assess for possible stroke inspired one program in Houston to follow suit. Supporters predict it will transform care in the future.

For 30-year-old Maureen Osaka, the first signs of stroke were dizziness followed by numbness in her left side. She was experiencing a basilar artery occlusion, a brain stem infarct with a mortality rate greater than 50 percent. Many patients with this type of stroke won’t make it to a hospital for treatment, and those who do survive often face lifelong severe disability.

Thankfully for her, a local stroke center in Houston had a new tool at its disposal: the Mobile Stroke Unit. The unit is the first of its kind in the U.S., a specially equipped ambulance with a CT scanner able to quickly assess patients and, if appropriate, speed the delivery of tissue plasminogen activator (tPA) to bust the clot. It was created in a partnership between the University of Texas Health Science Center at Houston (UTHealth) Medical School and Memorial Hermann-Texas Medical Center (TMC).

"We in the stroke community have always known treating a patient faster is better and that the major difference for stroke from other conditions is that we have to have that brain image before we can treat the patient,” says James C. Grotta, MD, the neurologist at Memorial Hermann-TMC who spearheaded the project. “We have always dreamt of doing that imaging pre-hospital.”

The window for tPA administration is brief, up to four and a half hours, depending on the patient. When the mobile stroke unit team arrived to treat Osaka, they confirmed the stroke using the onboard CT and began administering tPA on site—78 minutes after she first felt sick, according to Grotta. Days later she was back home, speaking and moving without deficit.

Inspired by Berlin

The mobile unit in Houston came about after Grotta visited Germany in 2012 and observed a similar project in Berlin. There, researchers were conducting the Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke Study (PHANTOM-S), in which the Stroke Emergency Mobile (STEMO) unit was dispatched to treat suspected strokes. Like the UTHealth mobile unit, STEMO is equipped with a CT scanner, point-of-care laboratory capability and telemedicine connectivity.

In coordination with the Berlin Fire Brigade, STEMO was dispatched 1,804 times over a 21-month period from 2011 to 2013, being utilized every other week so that treatment times could be compared against the use of conventional ambulances (JAMA 2014;311[16]:1622-1631). Some 177 patients were treated with tPA in the mobile stroke unit, and the intervention boosted treatment rates for ischemic strokes from 21 percent to 33 percent. STEMO allowed for a 25-minute reduction in time from alarm to tPA treatment, and 58 percent of patients were treated within 90 minutes of symptom onset compared with 37 percent in the control group.

Lead author of the study, Martin Ebinger, MD, of the neurology department at Charité–Universitätsmedizin Berlin, says STEMO reduced alarm-to-thrombolysis time without increasing risks. There were no CT malfunctions and the experience established the feasibility of telemedicine consultations on board a mobile stroke unit, though the reliability bar for connectivity necessarily must be set high and needs further testing.

“In these emergency situations you are looking for a reliability that is as close as possible to 100 percent,” says Ebinger. “With advancing technology, this goal is no longer out of reach.”

After seeing the positive results firsthand in Berlin along with an earlier study from Klaus Fassbender, MD, and colleagues in Homburg, Grotta and colleagues started raising money for the UTHealth mobile unit in early 2013. While STEMO used a much larger, specially designed ambulance, the project in Houston modified a standard 12-foot ambulance. The ambulance itself cost upwards of $150,000, the CT scanner nearly $400,000, and tens of thousands of additional dollars went into build-out expenses to accommodate the CT scanner and telemedicine connectivity.

Takeoff in Houston

But simply building a mobile stroke unit is only half the battle. There are also a number of bureaucratic hurdles in front of a project with this scope. "It's like starting a business from nothing," says Stephanie Parker, RN, BSN, project manager for the UTHealth Mobile Stroke Unit. Parker says protocol guidelines must be very specific for patient care