The National Heart, Lung and Blood Institute has granted the University of Illinois at Chicago (UIC) $12 million to bolster heart failure (HF) research, particularly to evaluate markers for diagnosis and treatment of the disease.
The five years of funding will support an ongoing project at the facility that is headed by R. John Solaro, PhD, which focuses on various aspects of HF. "We’re looking at the overarching problem of the maladaptive changes the heart undergoes that lead into a vicious cycle of failure," says Solaro, head of the department of physiology and biophysics at UIC.
Already, Solaro and colleagues have been involved in projects that have investigated energy consumption of the sarcomeres of the cardiac muscle and identified therapies for common familial cardiac disorders.
The current funding will focus on cellular metabolism."The interplay between protein function and expression in the heart, and metabolic processes in the cell, can either make or break the contractile function of the heart," said E. Douglas Lewandowski, PhD, professor in the physiology and biophysics department at UIC.