At 5 years, everolimus-eluting stent is superior to paclitaxel-eluting stent

After five years, patients undergoing PCI had better safety and efficacy outcomes if they received an everolimus-eluting stent (EES) compared with a paclitaxel-eluting stent (PES), according to the long-term analysis of a Dutch clinical trial.

The results, which were published online in JACC: Cardiovascular Interventions on July 22, confirmed previous findings at one and two years follow-up. The COMPARE trial evaluated a second-generation EES (XIENCE V from Abbott Vascular) and a second-generation PES (TAXUS Liberté from Boston Scientific).

Between February 2007 and September 2008, lead researcher Pieter C. Smits, MD, of Maasstad Hospital in Rotterdam, and colleagues randomized 1,800 patients in the Netherlands to receive one of the stents. At baseline, the groups were well-balanced. The median age was 63, and 70 percent of patients were males.

At five years, the EES group had a 27 percent relative risk reduction in the primary endpoint of death, nonfatal MI and target vessel revascularization (TVR). The benefits of EES were evident in all subgroups, according to the researchers. Patients who received the EES had significantly lower rates of MI (7.0 percent versus 11.5 percent) and TVR (7.4 percent versus 11.4 percent), but the groups had similar mortality rates (9.0 percent in the EES group and 10.3 percent in the PES group).

In addition, 12.5 percent of patients in the EES group experienced cardiac death, MI or clinically driven target lesion revascularization compared with 18.2 percent of patients in the PES group.

The researchers cited a few limitations, including that the results may not be applicable to all settings because the trial took place at one, high-volume, tertiary center. They also mentioned that PES is uncommon and that the study could not reliably estimate adverse events such as death or stent thrombosis.

Tim Casey,

Executive Editor

Tim Casey joined TriMed Media Group in 2015 as Executive Editor. For the previous four years, he worked as an editor and writer for HMP Communications, primarily focused on covering managed care issues and reporting from medical and health care conferences. He was also a staff reporter at the Sacramento Bee for more than four years covering professional, college and high school sports. He earned his undergraduate degree in psychology from the University of Notre Dame and his MBA degree from Georgetown University.

Around the web

Eleven medical societies have signed on to a consensus statement aimed at standardizing imaging for suspected cardiovascular infections.

Kate Hanneman, MD, explains why many vendors and hospitals want to lower radiology's impact on the environment. "Taking steps to reduce the carbon footprint in healthcare isn’t just an opportunity," she said. "It’s also a responsibility."

Philips introduced a new CT system at ECR aimed at the rapidly growing cardiac CT market, incorporating numerous AI features to optimize workflow and image quality.

Trimed Popup
Trimed Popup